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    • Ratio

    DERMAGENIST® PW

    Waking up sleeping beauty

    We all have a beauty potential for our skin. This beauty potential is locked deep within our skin cells’ genetic makeup. The fibroblasts in particular hold the keys to producing the components of the dermis. However, our lifestyle can alter this potential and accelerate skin ageing via epigenetic phenomena.

    The fibroblasts’ genetic code is not changed but following methylation, some genes are no longer expressed: the fibroblasts are “dormant” and their metabolic capacity is reduced.

    The fibroblasts’ optimal functioning is also ensured by a mechanical function. Their cytoskeleton, which is largely formed by actin fibers, gives them good traction strength and a better connection to the extracellular matrix (ECM).
    A dense actin cytoskeleton gives the fibroblasts good contractility and vitality, enabling them to synthesize the components of the dermal matrix correctly. This ability declines with age.

    The two phenomena lead to rarefaction of the collagen and loss of dermal density. The skin loses its tonicity.

    To reverse signs of ageing effectively and protect us against lifestyle damage, BASF experts are taking us deep into the fibroblasts with Dermagenist®, a marjoram extract rich in Vicenin and Luteolin-7-0-glucuronide, to re-establish their functions.

    Dermagenist® restores each fibroblast’s metabolic function by inhibiting the methylation of neutralized genes and strengthening its actin cytoskeleton to re-establish its mechanic function.

    Dermagenist® is clinically proven to work: the skin’s density and firmness are significantly improved.

    A youthful-looking appearance lies deep within the fibroblasts. Dermagenist™ awakens your dormant beauty.

    Product Description

    Standardized aqueous extract of Marjoram (Origanum Majorana) leaves

    Consumer Benefits

    Skin thickness / skin density increase, Firming

    In Vivo

    1. Improvement of skin density
    2. Improvement of skin firmness

    Ex Vivo/In Vitro/On Hair

    1. Expression and distribution of actin fibers in fibroblasts
    2. Fibroblast contractility
    3. Induction of BMP-1 synthesis
    4. LOXL1 promoter regulation by epigenetic DNA methylation
    5. Stimulation of collagen I synthesis
    6. Stimulation of fibrillar collagen organization

    Clinical Study Results

    Scientific Concept

    Target Molecules in the Skin

    Nature of Active

    Function

    • Elasticity & Firming

    Preservatives

    • None

    INCI

    • Maltodextrin (and) Origanum Majorana Leaf Extract

    Form of Delivery

    • Powder

    Application

    Product Group

    • Actives

    Claim Proposals

      Certificates

      Downloads

        Safety Data Sheets*

        • For Safety Data Sheets, please get in touch with your BASF contact, or directly go to WorldAccount.

        Related Formulations

          To see additional data, please log in with your BASF World Account details


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