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    Castaline® BC10133

    Relieve your atopic prone skin

    Atopic prone skin is a complex skin condition affecting consumers all around the world, impacting both their physical as well as their mental health. Castaline® is a multifunctional, mild solution to help calm atopic prone skin and to contribute to its visual improvement. It helps to support the skin’s natural physical, microbial and immune barriers in a three-defense-step action that has been demonstrated on a new, innovative 3D epidermis model, mimicking mild to moderate atopic prone skin. Castaline® helps to restore the skin's barrier function for a healthier looking and more comfortable skin.

    Product Description

    Extract of organic certified leaves of chestnut tree

    Consumer Benefits

    TEWL reduction / Cutaneous barrier strengthening, Calming, Moisturization, Soothing / Sensitivity decrease, Microbiome


    Extract of organic certified leaves of chestnut tree (Castanea sativa) rich in flavonoids, specifically in Astragalin and Miquelianin. Hand harvested in the French Ardèche and Cher area. Strengthens the physical, immune and microbial skin barrier and improves the condition of skin prone to atopic dermatitis.

    In Vivo

    1. Improvement of very dry skin condition (dermatologically rated according to local EASI score of the lesions)
    2. Reduction of TEWL
    3. Decrease of pH
    4. Self-assessment with improved perception of hydration
    5. Softness and soothing

    In Vitro / In Tubo

    1. Reduction of IL-8 release (Staphylococcus aureus- stressed macrophages)
    2. Reduction of IL-8 and IL-6 (Staphylococcus aureus- stressed keratinocytes)
    3. Increased epidermal protein expression (E- Cadherin, Claudin)
    4. Inhibition of Staphylococcus aureus biofilm formation
    5. Inhibition of enzymes released by Staphylococcus aureus (Lipase, Plasminogen, Hyaluronidase)
    6. Reduction of IL-8 release
    7. Increase of skin barrier proteins (Filaggrin, Loricrin, Claudin-1)
    8. Restoration of lamellar bodies traffic (Rab11a) and barrier morphology recovery (3D reconstructed Atopic Dermatitis Epidermidis)

    Clinical Study Results

    Target Molecules in the Skin

    Nature of Active


    • None


    • Glycerin Water Castanea Sativa (Chestnut) Leaf Extract

    Physical property

    • Liquid

    Claim Proposals



        Safety Data Sheets*

        • For Safety Data Sheets, please get in touch with your BASF contact, or directly go to WorldAccount.

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